USP L78 column: Mixed-mode silica: RP (>C8) + anion exchange
Silane carrying both a reversed-phase chain longer than C8 and an anion-exchange (amino) group, bonded to silica of 1-50 um.
Mode: mixed-mode Typical pH range: about 2-8 (silica base)
Typical uses
- Acidic drugs together with their counter-ions
- Polar and charged impurities
Common sizes (length x internal diameter, particle size)
- 250 x 4.6 mm, 5 um
- 150 x 4.6 mm, 3-5 um
Tender wording (brand-neutral)
HPLC column with USP L78 packing (Mixed-mode silica: RP (>C8) + anion exchange), 250 x 4.6 mm, 5 um (length x internal diameter, particle size); stainless-steel or equivalent hardware with standard fittings; recommended pH and temperature range to be stated by the bidder; each column supplied with its certificate of analysis and test chromatogram, batch/lot number and serial number; shelf life not less than 2 years from delivery; any make meeting the USP L78 designation and the stated dimensions is acceptable.
Size:
Changing length or particle size
You can keep the USP L78 packing and use a different length, particle size or diameter within the harmonized USP 621 limits. Check your columns with the calculator.
Related column types
L85 Mixed-mode silica: RP (>C8) + weak cation exchange
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