USP L95 column: Pentahydroxy polar ligand on porous silica (HILIC)
Porous silica particles, or a monolithic rod, bonded with a highly polar alkyl ligand carrying five hydroxyl groups.
Mode: HILIC Typical pH range: about 2-8 (silica base)
Typical uses
- Very polar drugs and metabolites by HILIC
- Polar impurities poorly retained on C18
Common sizes (length x internal diameter, particle size)
- 150 x 4.6 mm, 5 um
- 100 x 2.1 mm, 1.7-3.5 um
Tender wording (brand-neutral)
HPLC column with USP L95 packing (Pentahydroxy polar ligand on porous silica (HILIC)), 150 x 4.6 mm, 5 um (length x internal diameter, particle size); stainless-steel or equivalent hardware with standard fittings; recommended pH and temperature range to be stated by the bidder; each column supplied with its certificate of analysis and test chromatogram, batch/lot number and serial number; shelf life not less than 2 years from delivery; any make meeting the USP L95 designation and the stated dimensions is acceptable.
Size:
Changing length or particle size
You can keep the USP L95 packing and use a different length, particle size or diameter within the harmonized USP 621 limits. Check your columns with the calculator.
Related column types
L82 Polyamine on polyvinyl alcohol | L114 Zwitterionic sulfobetaine on silica
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