USP L17 column: SCX resin, H+ form (organic acid / ion-exclusion)
Strong cation-exchange resin of sulfonated, cross-linked styrene-divinylbenzene in the hydrogen form; particles 6-12 um.
Mode: ion-exchange Typical pH range: about 1-3 in use (dilute acid eluent); resin itself 1-14
Typical uses
- Organic acids by ion-exclusion with dilute acid eluent
- Sugars, alcohols and glycols
- Fermentation-type and excipient assays
Common sizes (length x internal diameter, particle size)
- 300 x 7.8 mm, 8-9 um
- 250 x 4.6 mm, 5 um
Usually run at elevated temperature (e.g. 35-65 C) with dilute sulfuric or phosphoric acid; avoid organic solvent above maker limits.
Example columns sold as USP L17
From the makers' own USP code lists and product pages, checked October 2026. Examples only, not an endorsement. Columns with the same code can still differ in selectivity; if the monograph names a column in its notes, start with that one.
| Maker | Product family | Particle | pH range |
|---|---|---|---|
| Agilent | Hi-Plex H | sulfonated PS-DVB resin, H+ form, 8 um | not stated in source |
| Phenomenex | Rezex RHM-Monosaccharide H+ (8%) | sulfonated PS-DVB resin, 8% cross-linked, H+ form | not stated in source |
| Hamilton | HC-75 (H+) | sulfonated PS-DVB resin, H+ form | not stated in source |
| Merck (Supelco) | SUPELCOGEL C-610H | sulfonated PS-DVB resin, H+ form | not stated in source |
| Shimadzu | Shim-pack SCR-101H | sulfonated PS-DVB resin, H+ form | not stated in source |
| Macherey-Nagel | NUCLEOGEL SUGAR 810 H | sulfonated PS-DVB resin, H+ form | not stated in source |
| Waters | IC-Pak Ion Exclusion | polymer resin, 7 um | not stated in source |
| Resonac (Shodex) | SUGAR SH1011 | sulfonated PS-DVB resin, H+ form | not stated in source |
| Welch Materials | Xtimate Sugar-H | sulfonated PS-DVB resin, H+ form | not stated in source |
9 makers listed, so a tender written by USP code stays open to competition.
Tender wording (brand-neutral)
HPLC column with USP L17 packing (SCX resin, H+ form (organic acid / ion-exclusion)), 300 x 7.8 mm, 8-9 um (length x internal diameter, particle size); stainless-steel or equivalent hardware with standard fittings; recommended pH and temperature range to be stated by the bidder; each column supplied with its certificate of analysis and test chromatogram, batch/lot number and serial number; shelf life not less than 2 years from delivery; any make meeting the USP L17 designation and the stated dimensions is acceptable.
Size:
Changing length or particle size
You can keep the USP L17 packing and use a different length, particle size or diameter within the harmonized USP 621 limits. Check your columns with the calculator.
Related column types
L9 SCX on silica | L14 SAX on silica | L19 SCX resin, Ca2+ form (sugars) | L22 Cation-exchange polystyrene gel (sulfonic) | L23 SAX polymethacrylate/polyacrylate gel | L34 SCX resin, Pb2+ form (sugar alcohols) | L46 SAX, latex-agglomerated PS-DVB (9-11 um) | L52 SCX silica (sulfopropyl / sulfoethyl) | L53 WCX resin, carboxylic/phosphonic grafted EVB-DVB (cations IC) | L58 SCX resin, Na+ form (sugars/oligosaccharides)
Not sure this is the right column? Use the step-by-step column selector.