USP L34 column: SCX resin, Pb2+ form (sugar alcohols)
Strong cation-exchange resin of sulfonated, cross-linked styrene-divinylbenzene in the lead form; particles about 7-9 um.
Mode: ion-exchange Typical pH range: about 5-9 (water eluent)
Typical uses
- Sorbitol, mannitol, maltitol and other polyols with water eluent
- Sugar excipient assays
Common sizes (length x internal diameter, particle size)
- 300 x 7.8 mm, 8-9 um
- 250 x 4.6 mm, 5 um
Run hot (typically 80-85 C) with pure water; contains lead - dispose of properly.
Example columns sold as USP L34
From the makers' own USP code lists and product pages, checked October 2026. Examples only, not an endorsement. Columns with the same code can still differ in selectivity; if the monograph names a column in its notes, start with that one.
| Maker | Product family | Particle | pH range |
|---|---|---|---|
| Agilent | Hi-Plex Pb | sulfonated PS-DVB resin, Pb2+ form, 8 um | not stated in source |
| Phenomenex | Rezex RPM-Monosaccharide Pb+2 (8%) | sulfonated PS-DVB resin, 8% cross-linked, Pb2+ form | not stated in source |
| Hamilton | HC-75 (Pb2+) | sulfonated PS-DVB resin, Pb2+ form | not stated in source |
| Merck (Supelco) | SUPELCOGEL Pb | sulfonated PS-DVB resin, Pb2+ form | not stated in source |
| Macherey-Nagel | NUCLEOGEL SUGAR Pb | sulfonated PS-DVB resin, Pb2+ form | not stated in source |
| Resonac (Shodex) | SUGAR SP0810 | sulfonated PS-DVB resin, Pb2+ form, 8 um (per Waters listing) | not stated in source |
6 makers listed, so a tender written by USP code stays open to competition.
Tender wording (brand-neutral)
HPLC column with USP L34 packing (SCX resin, Pb2+ form (sugar alcohols)), 300 x 7.8 mm, 8-9 um (length x internal diameter, particle size); stainless-steel or equivalent hardware with standard fittings; recommended pH and temperature range to be stated by the bidder; each column supplied with its certificate of analysis and test chromatogram, batch/lot number and serial number; shelf life not less than 2 years from delivery; any make meeting the USP L34 designation and the stated dimensions is acceptable.
Size:
Changing length or particle size
You can keep the USP L34 packing and use a different length, particle size or diameter within the harmonized USP 621 limits. Check your columns with the calculator.
Related column types
L9 SCX on silica | L14 SAX on silica | L17 SCX resin, H+ form (organic acid / ion-exclusion) | L19 SCX resin, Ca2+ form (sugars) | L22 Cation-exchange polystyrene gel (sulfonic) | L23 SAX polymethacrylate/polyacrylate gel | L46 SAX, latex-agglomerated PS-DVB (9-11 um) | L52 SCX silica (sulfopropyl / sulfoethyl) | L53 WCX resin, carboxylic/phosphonic grafted EVB-DVB (cations IC) | L58 SCX resin, Na+ form (sugars/oligosaccharides)
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